aggravation

definition: action that makes a problem, a disease, or its symptoms worse
example: The aggravation of my condition resulted from lack of care.
speech part: noun
synonyms: exacerbation
definition: unfriendly behavior that causes anger or resentment
example:
speech part: noun
synonyms: irritation provocation
definition: an exasperated feeling of annoyance
example:
speech part: noun
synonyms: exasperation

How aggravation is being used?